WIPOS 2022 featured four days of fantastic posters and short talks from leaders in the field of organic synthesis, with a healthy mixture of methods development, natural product synthesis, and chemical biology. The location of the conference also led to an impressive diversity of speakers, with research presented from all over the world and thus constituted a unique opportunity to network with new and interesting researchers. The atmosphere of the conference could be compared to a GRC, but with way superior food provided and lodging options. The banquet dinner was absolutely fantastic with selected options from a world-renown chef, and a boat tour of Waikiki Beach as a great optional activity.